I have this problem also (same error), it is intermittent for me though.
No idea what clears it up, after restarting the PSU, plugging/unplugging USB, different USB ports and even rebooting the PC It eventually functions again. Sometimes one or the other attempts results in function.
The next time it happens I will post my own thread with images of all the settings.
We know that IONI will not start up if there is too much EMI in the system and it cannot measure stable enough zero-values for analog current measurements. Thats why it can appear to be a bit strange sometimes.