It could be some type of a firmware issue. Power off, move the dip switches on Simucube, and power back up. You should see STM32 Bootloader. If you see it, then it is likely a firmware issue and you’ll need to reinstall firmware completely. If you don’t see STM32 Bootloader, then it is likely a hardware issue with the processor on the Simucube.
I also see that you have AsMedia USB controller. If you go to device manager, View menu, and select “Display devices by connection”, then you can get a hierarchial view of the system and you can check that the Simucube is not connected to the AsMedia controller.